Sniffing Through Scientific Research
Acupuncture and Acupressure
Dewey CW, Xie H. The scientific basis of acupuncture for veterinary pain management: A review based on relevant literature from the last two decades. Open Vet J. 2021 Apr-Jun;11(2):203-209. doi: 10.5455/OVJ.2021.v11.i2.3. Epub 2021 Apr 15. PMID: 34307076; PMCID: PMC8288732.
Huntingford JL, Petty MC. Evidence-Based Application of Acupuncture for Pain Management in Companion Animal Medicine. Vet Sci. 2022 May 26;9(6):252. doi: 10.3390/vetsci9060252. PMID: 35737304; PMCID: PMC9227989.
Silva NEOF, Luna SPL, Joaquim JGF, Coutinho HD, Possebon FS. Effect of acupuncture on pain and quality of life in canine neurological and musculoskeletal diseases. Can Vet J. 2017 Sep;58(9):941-951. PMID: 28878418; PMCID: PMC5556488. https://pmc.ncbi.nlm.nih.gov/articles/PMC5556488/
Bedsores
Caraty J, De Vreught L, Cachon T, Moissonnier P, Bongartz A, Viguier E, Carozzo C. Comparison of the different supports used in veterinary medicine for pressure sore prevention. J Small Anim Pract. 2019 Oct;60(10):623-630. doi: 10.1111/jsap.13061. Epub 2019 Jul 31. PMID: 31364781. https://pubmed.ncbi.nlm.nih.gov/31364781/
Swaim SF, Bradley DM, Vaughn DM, Powers RD, Hoffman CE. The greyhound dog as a model for studying pressure ulcers. Decubitus. 1993 Mar;6(2):32-5, 38-40. PMID: 8318156. https://pubmed.ncbi.nlm.nih.gov/8318156/
Cannabis
Nayak MM, Chai PR, Tung S, Sannes TS, Yusufov M, Braun IM. Letter to the Editor: The Role of Cannabidiol in Cancer Care: Oncologist and Cancer Patient Perspectives. Cannabis Cannabinoid Res. 2023 Apr;8(2):381-383. doi: 10.1089/can.2022.0033. Epub 2022 May 4. PMID: 35507954; PMCID: PMC10061323. https://pmc.ncbi.nlm.nih.gov/articles/PMC10061323/.
Coconut Oil
Seyfried TN, Mukherjee P, Lee DC, Ta L, Nations L. Case report: Resolution of malignant canine mast cell tumor using ketogenic metabolic therapy alone. Front Nutr. 2023 Mar 28;10:1157517. doi: 10.3389/fnut.2023.1157517. PMID: 37057065; PMCID: PMC10086349. https://pmc.ncbi.nlm.nih.gov/articles/PMC10086349/
Vecchiato CG, Pinna C, Sung CH, Borrelli De Andreis F, Suchodolski JS, Pilla R, Delsante C, Sportelli F, Mammi LME, Pietra M, Biagi G. Fecal Microbiota, Bile Acids, Sterols, and Fatty Acids in Dogs with Chronic Enteropathy Fed a Home-Cooked Diet Supplemented with Coconut Oil. Animals (Basel). 2023 Jan 31;13(3):502. doi: 10.3390/ani13030502. PMID: 36766392; PMCID: PMC9913398. https://pubmed.ncbi.nlm.nih.gov/36766392/
Curcumin
Campigotto G, Alba DF, Sulzbach MM, Dos Santos DS, Souza CF, Baldissera MD, Gundel S, Ourique AF, Zimmer F, Petrolli TG, Paiano D, Da Silva AS. Dog food production using curcumin as antioxidant: effects of intake on animal growth, health and feed conservation. Arch Anim Nutr. 2020 Oct;74(5):397-413. doi: 10.1080/1745039X.2020.1769442. Epub 2020 Jun 30. PMID: 32602378. https://pubmed.ncbi.nlm.nih.gov/32602378/
Comblain F, Barthélémy N, Lefèbvre M, Schwartz C, Lesponne I, Serisier S, Feugier A, Balligand M, Henrotin Y. A randomized, double-blind, prospective, placebo-controlled study of the efficacy of a diet supplemented with curcuminoids extract, hydrolyzed collagen and green tea extract in owner's dogs with osteoarthritis. BMC Vet Res. 2017 Dec 20;13(1):395. doi: 10.1186/s12917-017-1317-8. PMID: 29262825; PMCID: PMC5738810. https://pmc.ncbi.nlm.nih.gov/articles/PMC5738810/
Kępińska-Pacelik J, Biel W. Turmeric and Curcumin-Health-Promoting Properties in Humans versus Dogs. Int J Mol Sci. 2023 Sep 26;24(19):14561. doi: 10.3390/ijms241914561. PMID: 37834009; PMCID: PMC10572432. https://pmc.ncbi.nlm.nih.gov/articles/PMC10572432/
Levine CB, Bayle J, Biourge V, Wakshlag JJ. Cellular effects of a turmeric root and rosemary leaf extract on canine neoplastic cell lines. BMC Vet Res. 2017 Dec 13;13(1):388. doi: 10.1186/s12917-017-1302-2. PMID: 29237458; PMCID: PMC5729263. https://pmc.ncbi.nlm.nih.gov/articles/PMC5729263/
Garlic
Miraghajani M, Rafie N, Hajianfar H, Larijani B, Azadbakht L. Aged Garlic and Cancer: A Systematic Review. Int J Prev Med. 2018 Sep 17;9:84. doi: 10.4103/ijpvm.IJPVM_437_17. PMID: 30487964; PMCID: PMC6212616. https://pmc.ncbi.nlm.nih.gov/articles/PMC6212616/
Petrovic V, Nepal A, Olaisen C, Bachke S, Hira J, Søgaard CK, Røst LM, Misund K, Andreassen T, Melø TM, Bartsova Z, Bruheim P, Otterlei M. Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress. Nutrients. 2018 Apr 5;10(4):450. doi: 10.3390/nu10040450. PMID: 29621132; PMCID: PMC5946235. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946235/
Palliative Care
Goldberg KJ. Veterinary hospice and palliative care: a comprehensive review of the literature. Vet Rec. 2016 Apr 9;178(15):369-74. doi: 10.1136/vr.103459. PMID: 27056812.
Lam WWT, Fielding R, Choi LY. Optimizing palliative care and support for pets -perspectives of the pet-parent and the veterinarian. Front Vet Sci. 2023 May 19;10:1162269. doi: 10.3389/fvets.2023.1162269. PMID: 37275606; PMCID: PMC10235628.
Monteiro BP, de Lorimier LP, Moreau M, Beauchamp G, Blair J, Lussier B, Pelletier JP, Troncy E. Pain characterization and response to palliative care in dogs with naturally-occurring appendicular osteosarcoma: An open label clinical trial. PLoS One. 2018 Dec 6;13(12):e0207200. doi: 10.1371/journal.pone.0207200. PMID: 30521538; PMCID: PMC6283659.
Paz BF, Ferreira MGPA, Martins KR, Uccella L, Barboza de Nardi A. Practical Principles of Palliative Care in Veterinary Oncology: Alleviating the Suffering of the Animal, Owner, and Veterinarian. Vet Med Int. 2024 Jul 13;2024:5565837. doi: 10.1155/2024/5565837. PMID: 39035852; PMCID: PMC11260215.
Phytonutrients
Tanprasertsuk J, Tate DE, Shmalberg J. Roles of plant-based ingredients and phytonutrients in canine nutrition and health. J Anim Physiol Anim Nutr (Berl). 2022 May;106(3):586-613. doi: 10.1111/jpn.13626. Epub 2021 Sep 8. PMID: 34495560; PMCID: PMC9291198. https://pmc.ncbi.nlm.nih.gov/articles/PMC9291198/#:~:text=Yellow%E2%80%90orange%20vegetables%20and%20green,et%20al.%2C%202005)
Secondhand Smoke
Reif JS, Dunn K, Ogilvie GK, Harris CK. Passive smoking and canine lung cancer risk. Am J Epidemiol. 1992 Feb 1;135(3):234-9. doi: 10.1093/oxfordjournals.aje.a116276. PMID: 1546698. https://pubmed.ncbi.nlm.nih.gov/1546698/
Zierenberg-Ripoll A, Pollard RE, Stewart SL, Allstadt SD, Barrett LE, Gillem JM, Skorupski KA. Association between environmental factors including second-hand smoke and primary lung cancer in dogs. J Small Anim Pract. 2018 Jun;59(6):343-349. doi: 10.1111/jsap.12778. Epub 2017 Nov 14. PMID: 29134653; PMCID: PMC7491366. https://pmc.ncbi.nlm.nih.gov/articles/PMC7491366/
Osteosarcoma
Farcas N, Arzi B, Verstraete FJ. Oral and maxillofacial osteosarcoma in dogs: a review. Vet Comp Oncol. 2014 Sep;12(3):169-80. doi: 10.1111/j.1476-5829.2012.00352.x. Epub 2012 Aug 31. PMID: 22935032.
Martin TW, Griffin L, Custis J, Ryan SD, Lafferty M, Boss MK, Regan D, Rao S, Leary D, Withrow SJ, LaRue SM. Outcome and prognosis for canine appendicular osteosarcoma treated with stereotactic body radiation therapy in 123 dogs. Vet Comp Oncol. 2021 Jun;19(2):284-294. doi: 10.1111/vco.12674. Epub 2021 Jan 13. PMID: 33403752; PMCID: PMC8356246.
Misdorp W, Hart AA. Some prognostic and epidemiologic factors in canine osteosarcoma. J Natl Cancer Inst. 1979 Mar;62(3):537-45. doi: 10.1093/jnci/62.3.537. PMID: 283283.
O'Neill DG, Edmunds GL, Urquhart-Gilmore J, Church DB, Rutherford L, Smalley MJ, Brodbelt DC. Dog breeds and conformations predisposed to osteosarcoma in the UK: a VetCompass study. Canine Med Genet. 2023 Jun 27;10(1):8. doi: 10.1186/s40575-023-00131-2. PMID: 37365662; PMCID: PMC10294386.
Patkar S, Mannheimer J, Harmon SA, Ramirez CJ, Mazcko CN, Choyke PL, Brown GT, Turkbey B, LeBlanc AK, Beck JA. Large-Scale Comparative Analysis of Canine and Human Osteosarcomas Uncovers Conserved Clinically Relevant Tumor Microenvironment Subtypes. Clin Cancer Res. 2024 Dec 16;30(24):5630-5642. doi: 10.1158/1078-0432.CCR-24-1854. PMID: 39412757; PMCID: PMC11647208.
Szewczyk M, Lechowski R, Zabielska K. What do we know about canine osteosarcoma treatment? Review. Vet Res Commun. 2015 Mar;39(1):61-7. doi: 10.1007/s11259-014-9623-0. Epub 2014 Nov 26. PMID: 25422073; PMCID: PMC4330401.
T-Cell Lymphoma
Chen JJ, Tokumori FC, Del Guzzo C, Kim J, Ruan J. Update on T-Cell Lymphoma Epidemiology. Curr Hematol Malig Rep. 2024 Jun;19(3):93-103. doi: 10.1007/s11899-024-00727-w. Epub 2024 Mar 7. PMID: 38451372.
Dummer R, Vermeer MH, Scarisbrick JJ, Kim YH, Stonesifer C, Tensen CP, Geskin LJ, Quaglino P, Ramelyte E. Cutaneous T cell lymphoma. Nat Rev Dis Primers. 2021 Aug 26;7(1):61. doi: 10.1038/s41572-021-00296-9. PMID:
Ghilardi G, Fraietta JA, Gerson JN, Van Deerlin VM, Morrissette JJD, Caponetti GC, Paruzzo L, Harris JC, Chong EA, Susanibar Adaniya SP, Svoboda J, Nasta SD, Ugwuanyi OH, Landsburg DJ, Fardella E, Waxman AJ, Chong ER, Patel V, Pajarillo R, Kulikovskaya I, Lieberman DB, Cohen AD, Levine BL, Stadtmauer EA, Frey NV, Vogl DT, Hexner EO, Barta SK, Porter DL, Garfall AL, Schuster SJ, June CH, Ruella M. T cell lymphoma and secondary primary malignancy risk after commercial CAR T cell therapy. Nat Med. 2024 Apr;30(4):984-989. doi: 10.1038/s41591-024-02826-w. Epub 2024 Jan 24. PMID: 38266761.
Hristov AC, Tejasvi T, Wilcox RA. Cutaneous T-cell lymphomas: 2023 update on diagnosis, risk-stratification, and management. Am J Hematol. 2023 Jan;98(1):193-209. doi: 10.1002/ajh.26760. Epub 2022 Oct 20. PMID: 36226409; PMCID: PMC9772153.
Ma H, Abdul-Hay M. T-cell lymphomas, a challenging disease: types, treatments, and future. Int J Clin Oncol. 2017 Feb;22(1):18-51. doi: 10.1007/s10147-016-1045-2. Epub 2016 Oct 14. PMID: 27743148; PMCID: PMC7102240.
Varghese MT, Alsubait S. T-Cell Lymphoma. 2024 Mar 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 33232024.
Transitional Cell Carcinoma
Bryan JN, in Cote E (2nd ed), Clinical Veterinary Advisor: Dogs and Cats. Transitional Cell Carcinoma. Missouri, Mosby Elsevier, 2011, p 1112-1114.
Gilson SD, Stone EA. Surgically induced tumor-seeding in eight dogs and two cats. J Am Vet Med Assoc 196(11):1811, 1990.
Glickman LT, Schofer FS, McKee LF, et al. Epidemiologic study of insecticide exposures, obesity, and risk of bladder cancer in household dogs. J Tox Environ Health 28(4):407, 1989.
Glickman LT, Raghyavan M, Knapp DW et al. Herbicide exposure and the risk of transitional cell carcinoma of the urinary bladder in Scottish terrier dogs. J Am Vet Med Assoc 224:1290-1297, 2004.
Henry CJ, in Henry CJ, Higginbotham ML (ed): Cancer Management in Small Animal Practice. Bladder and Urethral Tumors. Missouri. Saunders Elsevier 2010, p 290-296.
Henry CJ. Management of Transitional Cell Carcinoma. Vet Clin Small Anim 33: 597-614, 2003.
Henry CJ, Tyler JW, McEntee MC, et al. Evaluation of a bladder tumor antigen test as a screening test for transitional cell carcinoma of the lower urinary tract in dogs. Am J Vet Res 64:1017, 2003.
Henry CJ, McCaw DL, Turnquist SE, et al. Clinical evaluation of mitoxantrone and piroxicam in a canine model of human invasive urinary bladder carcinoma. Clin Cancer Res 9:906, 2003.
Henry CJ, Tyler JW, McEntee MC, et al. Evaluation of a bladder tumor antigen test as a screening test for transitional cell carcinoma of the lower urinary tract in dogs. Am J Vet Res 64:1017, 2003.
Knapp DW, Richardson RC, Chan TC, et al. Piroxicam therapy in 34 dogs with transitional cell carcinoma of the urinary bladder. J Vet Int Med 8:273, 1994.
Mutsaers AJ, Widmer WR, Knapp DW. Canine transitional cell carcinoma. J Vet Intern Med 17:136, 2003.
Norris AM, Laing EJ, Valli VEO, et al. Canine bladder and urethral tumors: a retrospective study of 115 cases (1980-1985). J Vet Intern Med 6(3):145, 1992.
Nyland TG, Wallack ST, Wisner ER. Needle-tract implantation following US-guided fine-needle aspiration biopsy of transitional cell carcinoma of the bladder, urethra, and prostate. Vet Radiol Ultrasound 43(1):50, 2002.
Poirier VJ, Forrest LJ, Adams WM, et al. Piroxicam, mitoxantrone, and course fraction radiotherapy for the treatment of transitional cell carcinoma of the bladder in 10 dogs: a pilot study. J Am Anim Hosp Assoc 40:131, 2004.
Raghavan M, Knapp DW, Bonney PL, et al. Evaluation of the effect of dietary vegetable consumption on reducing risk of transitional cell carcinoma of the urinary bladder in Scottish Terriers. J Am Vet Med Assoc. 227(1):94-100. 2005.
Rocha TA, Mauldin GN, Patnaik AK, et al. Prognostic factors in dogs with urinary bladder carcinoma. J Vet Intern Med 14(5): 486-90.
Upton ML, Tangner CH, Payton ME. Evaluation of carbon dioxide laser ablation combined with mitoxantrone and piroxicam treatment in dogs with transitional cell carcinoma. J Am Vet Med Assoc 228:549, 2006.
Walter PA, Haynes JS, Feeney DA, et al. Radiographic appearance of pulmonary metastases from transitional cell carcinoma of the bladder and urethra of the dog. J Am Vet Med Assoc 185(4):411, 1984.
Withrow SJ, Vail DM (eds): Withrow & MacEwen’s Small Animal Clinical Oncology. St Louis Missouri, Saunders Elsevier, 2007, pp 649-658. Tumors of the urinary system. Knapp DW.
Vision Loss
Komáromy AM, Abrams KL, Heckenlively JR, Lundy SK, Maggs DJ, Leeth CM, MohanKumar PS, Petersen-Jones SM, Serreze DV, van der Woerdt A. Sudden acquired retinal degeneration syndrome (SARDS) - a review and proposed strategies toward a better understanding of pathogenesis, early diagnosis, and therapy. Vet Ophthalmol. 2016 Jul;19(4):319-31. doi: 10.1111/vop.12291. Epub 2015 Jun 20. PMID: 26096588.
Montgomery KW, van der Woerdt A, Cottrill NB. Acute blindness in dogs: sudden acquired retinal degeneration syndrome versus neurological disease (140 cases, 2000-2006). Vet Ophthalmol. 2008 Sep-Oct;11(5):314-20. doi: 10.1111/j.1463-5224.2008.00652.x. PMID: 19046291.
T-Cell Therapy
Mochel JP, Ekker SC, Johannes CM, Jergens AE, Allenspach K, Bourgois-Mochel A, Knouse M, Benzekry S, Wierson W, LeBlanc AK, Kenderian SS. CAR T Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies. AAPS J. 2019 Apr 8;21(3):50. doi: 10.1208/s12248-019-0322-1. PMID: 30963322.
O'Connor CM, Wilson-Robles H. Developing T cell cancer immunotherapy in the dog with lymphoma. ILAR J. 2014;55(1):169-81. doi: 10.1093/ilar/ilu020. PMID: 24936037.
Panjwani MK, Atherton MJ, MaloneyHuss MA, Haran KP, Xiong A, Gupta M, Kulikovsaya I, Lacey SF, Mason NJ. Establishing a model system for evaluating CAR T cell therapy using dogs with spontaneous diffuse large B cell lymphoma. Oncoimmunology. 2019 Oct 23;9(1):1676615. doi: 10.1080/2162402X.2019.1676615. PMID: 32002286; PMCID: PMC6959441.
Zhang S, Black RG, Kohli K, Hayes BJ, Miller C, Koehne A, Schroeder BA, Abrams K, Schulte BC, Alexiev BA, Heimberger AB, Zhang A, Jing W, Ng JCK, Shinglot H, Seguin B, Salter AI, Riddell SR, Jensen MC, Gottschalk S, Moore PF, Torok-Storb B, Pollack SM. B7-H3 Specific CAR T Cells for the Naturally Occurring, Spontaneous Canine Sarcoma Model. Mol Cancer Ther. 2022 Jun 1;21(6):999-1009. doi: 10.1158/1535-7163.MCT-21-0726. PMID: 35405743; PMCID: PMC9381119.
Vaccination
Adkins B, Bu Y, Guevara P. The generation of Th memory in neonates versus adults: prolonged primary Th2 effector function and impaired development of Th1 memory effector function in murine neonates. J Immunol. 2001 Jan 15;166(2):918-25.
Adkins B. Development of neonatal Th1/Th2 function. Int Rev Immunol. 2000;19(2-3):157-71. Review.
Becker Y. Molecular immunological approaches to biotherapy of human cancers–a review, hypothesis and implications. Anticancer Res. 2006 Mar-Apr;26(2A):1113-34. Review.
Knutson KL, Disis ML. Cancer Immunol Immunother. Tumor antigen-specific T helper cells in cancer immunity and immunotherapy. 2005 Aug;54(8):721-8. Epub 2005 Jan 27. Review.
Kovarik J, Siegrist CA. Optimization of vaccine responses in early life: the role of delivery systems and immunomodulators. Immunol Cell Biol. 1998 Jun;76(3):222-36. Review.
Roberts AI, Devadas S, Zhang X, Zhang L, Keegan A, Greeneltch K, Solomon J, Wei L, Das J, Sun E, Liu C, Yuan Z, Zhou JN, Shi Y. Immunol Res. The role of activation-induced cell death in the differentiation of T-helper-cell subsets. 2003;28(3):285-93. Review.
Tatsumi, T et al. Disease-associated Bias in T Helper Type 1 (Th1)/Th2 CD4+ T Cell Responses Against MAGE-6 in HLA-DRB1*0401+ Patients With Renal Cell Carcinoma or Melanoma. J Exp Med. 2002 September 2; 196(5): 619–628.
Water
Bassin EB, et al. Age-specific fluoride exposure in drinking water and osteosarcoma (United States). Cancer Causes Control. 2006 May;17(4):421-8.
Browne ML, Varadarajulu D, Lewis-Michl EL, Fitzgerald EF. Cancer incidence and asbestos in drinking water, Town of Woodstock, New York, 1980-1998. Environ Res. 2005 Jun;98(2):224-32.
Cantor KP. Drinking water and cancer. Cancer Causes Control. 1997 May;8(3):292-308. Review.
Collegium Ramazzini. Asbestos is still with us: repeat call for a universal ban. Int J Occup Environ Health. 2010 Jul-Sep;16(3):351-5.
Eilperin, J. The Washington Post. Washington, DC. Associated Press Investigative Series on Water Quality Professor at Harvard Is Being Investigated; Fluoride-Cancer Link May Have Been Hidden. The Washington Post Company, 2008.
Esplugas S, et al. Ozonation and advanced oxidation technologies to remove endocrine disrupting chemicals (EDCs) and pharmaceuticals and personal care products (PPCPs) in water effluents. J Hazard Mater. 2007 Nov 19;149(3):631-42. Epub 2007 Jul 28.
Heberer T, Reddersen K, Mechlinski A. From municipal sewage to drinking water: fate and removal of pharmaceutical residues in the aquatic environment in urban areas. Water Sci Technol. 2002;46(3):81-8.
Ikonomou MG, et. al. Ultra-trace analysis of multiple endocrine-disrupting chemicals in municipal and bleached kraft mill effluents using gas chromatography-high-resolution mass spectrometry. Environ Toxicol Chem. 2008 Feb;27(2):243-51.
LaDou J. The asbestos cancer epidemic. Environ Health Perspect. 2004 Mar;112(3):285-90.
Petrovic M, et al. Fate and removal of pharmaceuticals and illicit drugs in conventional and membrane bioreactor wastewater treatment plants and by riverbank filtration. Philos Transact A Math Phys Eng Sci. 2009 Oct 13;367(1904):3979-4003.
Polissar L, Severson RK, Boatman ES, Thomas DB. Cancer incidence in relation to asbestos in drinking water in the Puget Sound region. Am J Epidemiol. 1982 Aug;116(2):314-28.
Pomati F, Orlandi C, Clerici M, Luciani F, Zuccato E. Effects and interactions in an environmentally relevant mixture of pharmaceuticals. Toxicol Sci. 2008 Mar;102(1):129-37. Epub 2007 Nov 28.
Richardson SD, et al. Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research. Mutat Res. 2007 Nov-Dec;636(1-3):178-242. Epub 2007 Sep 12. Review.
Ternes TA, et al. Removal of pharmaceuticals during drinking water treatment. Environ Sci Technol. 2002 Sep 1;36(17):3855-63.
Ward MH, Rusiecki JA, Lynch CF, Cantor KP. Nitrate in public water supplies and the risk of renal cell carcinoma. Cancer Causes Control. 2007
Weyer PJ, et al. Municipal drinking water nitrate level and cancer risk in older women: the Iowa Women’s Health Study. Epidemiology. 2001 May;12(3):327-38.
